• 产品名称Anti-GRIM19抗体
    参阅全部 GRIM19 一抗
  • 描述
    兔多克隆抗体to GRIM19
  • 特异性Reacts with the human GRIM-19 protein.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 常规说明

    Antisense expression of GRIM 19 (Genes associated with Retinoid-IFN-induced Mortality) confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM 19 protein. Overexpression of GRIM 19 enhances cell death in response to IFN/RA. GRIM 19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM 19 is a novel cell death-regulatory molecule.



Our Abpromise guarantee covers the use of ab3449 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).


  • 功能Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
  • 组织特异性Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
  • 疾病相关Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
  • 序列相似性Belongs to the complex I NDUFA13 subunit family.
  • 发展阶段Expressed in numerous fetal tissues.
  • 细胞定位Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2700054G14Rik antibody
    • AU022060 antibody
    • B16.6 antibody
    • CDA016 antibody
    • Cell death regulatory protein antibody
    • Cell death regulatory protein GRIM-19 antibody
    • CGI-39 antibody
    • CGI39 protein antibody
    • CI-B16.6 antibody
    • Complex I-B16.6 antibody
    • FLJ58045 antibody
    • FLJ59191 antibody
    • Gene associated with retinoic and IFN-induced mortality 19 protein antibody
    • Gene associated with retinoic and interferon-induced mortality 19 protein antibody
    • Gene associated with retinoic interferon induced mortality 19 protein antibody
    • GRIM-19 antibody
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody
    • NADH ubiquinone oxidoreductase B16.6 subunit antibody
    • NADH-ubiquinone oxidoreductase B16.6 subunit antibody
    • NDUAD_HUMAN antibody
    • NDUFA13 antibody
    • RGD1565358 antibody
    see all

Anti-GRIM19 antibody (ab3449)参考文献

ab3449 has not yet been referenced specifically in any publications.