The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-GRIK1 antibody (ab67317)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium azide Constituent: PBS
Excitatory amino acid receptor 3
Glutamate receptor 5
Glutamate receptor ionotropic kainate 1
Human glutamate receptor GLUR5
ionotropic kainate 1
功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
组���特异性Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.