概述

  • 产品名称Anti-GRIK1抗体
    参阅全部 GRIK1 一抗
  • 描述
    兔多克隆抗体to GRIK1
  • 经测试应用适用于: ICC/IF, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 16 amino acids peptide from near the center of Human GRIK1

  • 阳性对照
    • rat brain tissue lysate, human brain tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab67317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 104 kDa (predicted molecular weight: 104 kDa).Can be blocked with GRIK1 peptide (ab115358).
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • 组织特异性Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
  • 细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EAA3 antibody
    • EEA3 antibody
    • Excitatory amino acid receptor 3 antibody
    • GLR5 antibody
    • GluR-5 antibody
    • GluR5 antibody
    • GluR6 antibody
    • GluR7 antibody
    • Glutamate receptor 5 antibody
    • Glutamate receptor antibody
    • Glutamate receptor ionotropic kainate 1 antibody
    • GRIK1 antibody
    • GRIK1_HUMAN antibody
    • Human glutamate receptor GLUR5 antibody
    • ionotropic kainate 1 antibody
    • OTTHUMP00000096569 antibody
    see all

Anti-GRIK1 antibody 图像

  • Lane 1 : Anti-GRIK1 antibody (ab67317) at 0.5 µg/ml
    Lane 2 : Anti-GRIK1 antibody (ab67317) at 1 µg/ml

    Lane 1 : rat brain tissue lysate
    Lane 2 : rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 104 kDa
    Observed band size : 104 kDa
    Additional bands at : 85 kDa. We are unsure as to the identity of these extra bands.
  •  ab67317 at 2.5 μg/ml staining of GRIK1 in human brain tissue using IHC-P
  • Immunofluorescence of Grik1 in Human Brain cells using ab67317 at 20 ug/ml.

Anti-GRIK1 antibody (ab67317)参考文献

ab67317 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab67317.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"