概述

  • 产品名称Anti-GRIK1抗体
    参阅全部 GRIK1 一抗
  • 描述
    兔多克隆抗体to GRIK1
  • 经测试应用适用于: ICC/IF, IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    A 15 amino acid synthetic peptide designed near the C-terminus of Human GRIK1.

  • 阳性对照
    • P815 cells. Brain tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab67316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 104 kDa (predicted molecular weight: 104 kDa).

靶标

  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • 组织特异性Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
  • 细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EAA3 antibody
    • EEA3 antibody
    • Excitatory amino acid receptor 3 antibody
    • GLR5 antibody
    • GluR-5 antibody
    • GluR5 antibody
    • GluR6 antibody
    • GluR7 antibody
    • Glutamate receptor 5 antibody
    • Glutamate receptor antibody
    • Glutamate receptor ionotropic kainate 1 antibody
    • GRIK1 antibody
    • GRIK1_HUMAN antibody
    • Human glutamate receptor GLUR5 antibody
    • ionotropic kainate 1 antibody
    • OTTHUMP00000096569 antibody
    see all

Anti-GRIK1 antibody 图像

  • Lane 1 : Anti-GRIK1 antibody (ab67316) at 0.5 µg/ml
    Lane 2 : Anti-GRIK1 antibody (ab67316) at 1 µg/ml
    Lane 3 : Anti-GRIK1 antibody (ab67316) at 2 µg/ml

    Lane 1 : P815 cell lysate
    Lane 2 : P815 cell lysate
    Lane 3 : P815 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 104 kDa
    Observed band size : 104 kDa
    Additional bands at : 95 kDa. We are unsure as to the identity of these extra bands.
  • ab67316 at 2.5 μg/ml staining of GRIK1 in human brain tissue using IHC-P.
  • Immunofluorescence of Grik1 in Human Brain cells using ab67316 at 20 ug/ml.

Anti-GRIK1 antibody (ab67316)参考文献

ab67316 has not yet been referenced specifically in any publications.

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