Anti-GRF2 (phospho Y504)抗体(ab74068)

概述

  • 产品名称Anti-GRF2 (phospho Y504)抗体
    参阅全部 GRF2 一抗
  • 描述
    兔多克隆抗体to GRF2 (phospho Y504)
  • 特异性ab74068 detects endogenous levels of GRF2 only when phosphorylated at tyrosine 504 (Human: Tyr504; Mouse: Tyr514).
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human GRF2 around the phosphorylation site of tyrosine 504 (V-P-YP-A-P)

  • 阳性对照
    • Extracts from HepG2 cells treated with Na3VO4 (0.3nM, 40mins).

性能

应用

Our Abpromise guarantee covers the use of ab74068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 121 kDa (predicted molecular weight: 121 kDa).
ELISA 1/10000.

靶标

  • 功能Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS.
  • 组织特异性Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.
  • 序列相似性Contains 1 N-terminal Ras-GEF domain.
    Contains 1 Ras-GEF domain.
  • Information by UniProt
  • 数据库链接
  • 形式It localizes to cytoplasm and endosomes.
  • 别名
    • C3G antibody
    • C3G protein antibody
    • CRK SH3 binding GNRP antibody
    • CRK SH3-binding GNRP antibody
    • DKFZp781P1719 antibody
    • GRF 2 antibody
    • GRF2 antibody
    • Guanine nucleotide releasing factor 2 (specific for crk proto oncogene) antibody
    • Guanine nucleotide releasing factor 2 antibody
    • Guanine nucleotide-releasing factor 2 antibody
    • OTTHUMP00000064558 antibody
    • Protein C3G antibody
    • Rap guanine nucleotide exchange factor (GEF) 1 antibody
    • Rap guanine nucleotide exchange factor 1 antibody
    • RAPGEF 1 antibody
    • RAPGEF1 antibody
    • RPGF1_HUMAN antibody
    see all

Anti-GRF2 (phospho Y504) antibody 图像

  • All lanes : Anti-GRF2 (phospho Y504) antibody (ab74068) at 1/500 dilution

    Lane 1 : Extracts from HepG2 cells treated with Na3VO4 (0.3nM, 40mins),
    Lane 2 : Extracts from HepG2 cells treated with Na3VO4 (0.3nM, 40mins) with immunising phosphopeptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 121 kDa
    Observed band size : 121 kDa

Anti-GRF2 (phospho Y504) antibody (ab74068)参考文献

ab74068 has not yet been referenced specifically in any publications.

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