Anti-Gremlin 1抗体(ab57139)

概述

  • 产品名称Anti-Gremlin 1抗体
    参阅全部 Gremlin 1 一抗
  • 描述
    小鼠单克隆抗体to Gremlin 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 75-185 of Human Gremlin 1

性能

应用

Our Abpromise guarantee covers the use of ab57139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

靶标

  • 功能Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
  • 组织特异性Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
  • 疾病相关Polyposis syndrome, mixed hereditary 1
  • 序列相似性Belongs to the DAN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BMP antagonist 1 antibody
    • Cell proliferation inducing gene 2 protein antibody
    • Cell proliferation-inducing gene 2 protein antibody
    • CKTSF1B1 antibody
    • colorectal adenoma and carcinoma 1 antibody
    • Cysteine knot superfamily 1 antibody
    • Cysteine knot superfamily 1, BMP antagonist 1 antibody
    • Cysteine knot superfamily BMP antagonist 1 antibody
    • DAN domain family member 2 antibody
    • DAND2 antibody
    • Down regulated in Mos-transformed cells protein antibody
    • Down-regulated in Mos-transformed cells protein antibody
    • DRM antibody
    • grem1 antibody
    • GREM1_HUMAN antibody
    • Gremlin 1 homolog, cysteine knot superfamily antibody
    • Gremlin 1 like protein antibody
    • Gremlin 1, cysteine knot superfamily, homolog antibody
    • GREMLIN antibody
    • Gremlin-1 antibody
    • Gremlin1 antibody
    • IHG-2 antibody
    • IHG2 antibody
    • Increased in high glucose 2 antibody
    • Increased in high glucose protein 2 antibody
    • PIG2 antibody
    • Proliferation inducing gene 2 antibody
    • proliferation inducing gene 2 protein antibody
    see all

Anti-Gremlin 1 antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab57139 Gremlin 1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

Anti-Gremlin 1 antibody (ab57139)参考文献

ab57139 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Liver)
Specification Liver
Fixative Formalin
Antigen retrieval step Other
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5%
Username

Abcam user community

Verified customer

提交于 Jan 31 2012

I am very pleased to hear you would like to accept our offer and test ab57139 in IHC-P. This code will give you 1 free primary antibody before the expiration date. To redeem this offer, please submit an Abreview for IHC-P and include this code in the “...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"