概述

  • 产品名称Anti-GRB2抗体[M331]
    参阅全部 GRB2 一抗
  • 描述
    小鼠单克隆抗体[M331] to GRB2
  • 经测试应用适用于: WB, IP, ELISAmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    Recombinant full length Rat protein

  • 阳性对照
    • PC12 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab86713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 24 kDa.
IP 1/50.
ELISA 1/2000.

靶标

  • 功能Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
    Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
  • 序列相似性Belongs to the GRB2/sem-5/DRK family.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • 结构域The SH3 domains mediate interaction with RALGPS1 and SHB.
  • 细胞定位Golgi apparatus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Abundant SRC homology antibody
    • Adapter protein GRB2 antibody
    • ASH antibody
    • Ash protein antibody
    • EGFRBP GRB2 antibody
    • Epidermal growth factor receptor binding protein antibody
    • Epidermal growth factor receptor binding protein GRB2 antibody
    • GRB 2 antibody
    • GRB2 adapter protein antibody
    • Grb2 antibody
    • GRB2_HUMAN antibody
    • Grb3 3 antibody
    • Growth factor receptor bound protein 2 antibody
    • Growth factor receptor bound protein 3 antibody
    • Growth factor receptor-bound protein 2 antibody
    • HT027 antibody
    • MST084 antibody
    • MSTP084 antibody
    • NCKAP2 antibody
    • OTTHUMP00000166096 antibody
    • OTTHUMP00000166097 antibody
    • OTTHUMP00000166098 antibody
    • Protein ash antibody
    • SEM5 antibody
    • SH2/SH3 adapter GRB2 antibody
    see all

Anti-GRB2 antibody [M331] 图像

  • Lane 1 : Anti-GRB2 antibody [M331] (ab86713) at 1/250 dilution
    Lane 2 : Anti-GRB2 antibody [M331] (ab86713) at 1/500 dilution
    Lane 3 : Anti-GRB2 antibody [M331] (ab86713) at 1/1000 dilution

    Lane 1 : PC12 cell lysate
    Lane 2 : PC12 cell lysate
    Lane 3 : PC12 cell lysate


    Observed band size : 24 kDa (why is the actual band size different from the predicted?)

Anti-GRB2 antibody [M331] (ab86713)参考文献

This product has been referenced in:
  • Spangle JM & Munger K The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog 9:e1003237 (2013). WB ; Human . Read more (PubMed: 23516367) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab86713.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"