概述

  • 产品名称Anti-Granzyme B抗体[GB11]
    参阅全部 Granzyme B 一抗
  • 描述
    小鼠单克隆抗体[GB11] to Granzyme B
  • 经测试应用适用于: Flow Cyt, IHC-Fr, IPmore details
  • 种属反应性
    与反应: Human, Chimpanzee, Monkey, Rhesus monkey
  • 免疫原

    Full length native protein (purified) (Human).

  • 常规说明This product should be stored undiluted. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

应用

Our Abpromise guarantee covers the use of ab10912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
IHC-Fr
IP
  • 应用说明Flow Cyt: 1/10 - 1/100. Membrane permeabilization is required for flow cytometry. The use of LeucopermTM is recommended for this purpose. Use 10µl of the suggested working dilution to label 106 cells or 100ul whole blood.
    IHC-Fr: Use at an assay dependent dilution. Hsi, B-L. et al. (1986)
    IP: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
    • 序列相似性Belongs to the peptidase S1 family. Granzyme subfamily.
      Contains 1 peptidase S1 domain.
    • 细胞定位Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C11 antibody
      • Cathepsin G like 1 antibody
      • Cathepsin G-like 1 antibody
      • CCPI antibody
      • CGL 1 antibody
      • CGL1 antibody
      • CSP B antibody
      • CSPB antibody
      • CTLA-1 antibody
      • CTLA1 antibody
      • CTSGL1 antibody
      • Cytotoxic serine protease B antibody
      • Cytotoxic T lymphocyte associated serine esterase 1 antibody
      • Cytotoxic T lymphocyte proteinase 2 antibody
      • Cytotoxic T-lymphocyte proteinase 2 antibody
      • Fragmentin 2 antibody
      • Fragmentin-2 antibody
      • GRAB_HUMAN antibody
      • Granzyme 2 antibody
      • Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody
      • Granzyme B antibody
      • Granzyme-2 antibody
      • GranzymeB antibody
      • GRB antibody
      • Gzmb antibody
      • Hlp antibody
      • Human lymphocyte protein antibody
      • Lymphocyte protease antibody
      • Protease, serine, B antibody
      • SECT antibody
      • T cell serine protease 1-3E antibody
      • T-cell serine protease 1-3E antibody
      see all

    Anti-Granzyme B antibody [GB11] (ab10912)参考文献

    This product has been referenced in:
    • Demotte N  et al. A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice. Cancer Res 70:7476-88 (2010). Flow Cyt ; Human . Read more (PubMed: 20719885) »

    See 1 Publication for this product

    Product Wall

    Thank you for contacting Abcam.

    The main difference between ab103157, Granzyme B antibody [CLB-GB11] (FITC) and ab10912, -Granzyme B antibody [ GB11 ] is that ab103157 is conjugated to a FITC tag, whereas ab10912 is unconjugated. Also althoug...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"