概述

  • 产品名称
    Anti-Granulin抗体
    参阅全部 Granulin 一抗
  • 描述
    山羊多克隆抗体to Granulin
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow
  • 免疫原

    Synthetic peptide:

    QSKCLSKENATTD

    , corresponding to internal sequence amino acids 257-269 of Human Granulin (NP_002078.1)

  • 阳性对照
    • A549 and HeLa lysates.

性能

应用

Our Abpromise guarantee covers the use of ab85342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 64 kDa (predicted molecular weight: 64 kDa).

靶标

  • 功能
    Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
    Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
  • 组织特异性
    In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
  • 疾病相关
    Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
  • 序列相似性
    Belongs to the granulin family.
  • 翻译后修饰
    Granulins are disulfide bridged.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acrogranin antibody
    • CLN11 antibody
    • GEP antibody
    • GP88 antibody
    • Granulin A antibody
    • Granulin B antibody
    • Granulin C antibody
    • Granulin D antibody
    • Granulin E antibody
    • Granulin epithelin antibody
    • Granulin F antibody
    • Granulin G antibody
    • Granulin-7 antibody
    • Granulins antibody
    • GRN antibody
    • GRN_HUMAN antibody
    • PC cell derived growth factor antibody
    • PCDGF antibody
    • PEPI antibody
    • PGRN antibody
    • Proepithelin antibody
    • Progranulin antibody
    see all

Anti-Granulin antibody 图像

  • Anti-Granulin antibody (ab85342) at 1 µg + HeLa lysate at 35 µg

    Predicted band size : 64 kDa
    Observed band size : 64 kDa

实验方案

Anti-Granulin antibody (ab85342)参考文献

ab85342 has not yet been referenced specifically in any publications.

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