概述

  • 产品名称Anti-GRAF抗体
    参阅全部 GRAF 一抗
  • 描述
    小鼠多克隆抗体to GRAF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human GRAF (AAH68555.1, amino acids 1-759)

  • 阳性对照
    • GRAF transfected 293T cell lysate, HepG2 cell lysate and Human placenta tissue lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab89783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: Isoform 2, 86 kDa; Isoform 1, 94 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能GTPase-activating protein for RHOA and CDC42.
    • 疾病相关Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
    • 序列相似性Contains 1 PH domain.
      Contains 1 Rho-GAP domain.
      Contains 1 SH3 domain.
    • 细胞定位Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
    • Information by UniProt
    • 数据库链接
    • 别名
      • arhgap26 antibody
      • FLJ42530 antibody
      • GRAF antibody
      • GRAF1 antibody
      • GTPase regulator associated with focal adhesion kinase antibody
      • GTPase regulator associated with focal adhesion kinase pp125(FAK) antibody
      • KIAA0621 antibody
      • oligophrenin 1 like protein antibody
      • Oligophrenin-1-like protein antibody
      • oligophrenin1like protein antibody
      • OPHN1L antibody
      • OPHN1L1 antibody
      • RHG26_HUMAN antibody
      • Rho GTPase activating protein 26 antibody
      • Rho GTPase activating protein26 antibody
      • Rho GTPase-activating protein 26 antibody
      • Rho-type GTPase-activating protein 26 antibody
      see all

    Anti-GRAF antibody 图像

    • Anti-GRAF antibody (ab89783) at 1 µg/ml + human placenta tissue lysate at 50 µg

      Predicted band size : 86 kDa
      Observed band size : 76 kDa (why is the actual band size different from the predicted?)
    • Anti-GRAF antibody (ab89783) at 1 µg/ml + HepG2 cell lysate at 50 µg

      Predicted band size : 86 kDa
      Observed band size : 86 kDa
    • All lanes : Anti-GRAF antibody (ab89783) at 1 µg/ml

      Lane 1 : GRAF transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.


      Predicted band size : 86 kDa
      Observed band size : 86 kDa

    Anti-GRAF antibody (ab89783)参考文献

    This product has been referenced in:
    • Cai B  et al. GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation. Front Cell Dev Biol 2:22 (2014). Read more (PubMed: 25364729) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"