概述

  • 产品名称Anti-GRAF抗体
    参阅全部 GRAF 一抗
  • 描述
    山羊多克隆抗体to GRAF
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    KTGLIPENYVEFL

    , corresponding to C terminal amino acids 802-814 of Human GRAF.

  • 阳性对照
    • Heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab15916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 2 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 94 kDa).

靶标

  • 功能GTPase-activating protein for RHOA and CDC42.
  • 疾病相关Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
  • 序列相似性Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
    Contains 1 SH3 domain.
  • 细胞定位Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
  • Information by UniProt
  • 数据库链接
  • 别名
    • arhgap26 antibody
    • FLJ42530 antibody
    • GRAF antibody
    • GRAF1 antibody
    • GTPase regulator associated with focal adhesion kinase antibody
    • GTPase regulator associated with focal adhesion kinase pp125(FAK) antibody
    • KIAA0621 antibody
    • oligophrenin 1 like protein antibody
    • Oligophrenin-1-like protein antibody
    • oligophrenin1like protein antibody
    • OPHN1L antibody
    • OPHN1L1 antibody
    • RHG26_HUMAN antibody
    • Rho GTPase activating protein 26 antibody
    • Rho GTPase activating protein26 antibody
    • Rho GTPase-activating protein 26 antibody
    • Rho-type GTPase-activating protein 26 antibody
    see all

Anti-GRAF antibody 图像

  • All lanes : Anti-GRAF antibody (ab15916) at 0.3 µg/ml

    Lane 1 : (A) Human Heart lysate
    Lane 2 : (B) Human Heart lysate with immunizing peptide

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 94 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 16 kDa. We are unsure as to the identity of these extra bands.

Anti-GRAF antibody (ab15916)参考文献

ab15916 has not yet been referenced specifically in any publications.

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