概述

  • 产品名称
  • 描述
    兔多克隆抗体to GPSM2
  • 经测试应用
    适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Chimpanzee, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between amino acids 450-500 of Human GPSM2 (AAH27732.1).

  • 阳性对照
    • HeLa whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab110147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
    • 组织特异性
      Ubiquitously expressed.
    • 疾病相关
      Defects in GPSM2 are the cause of deafness autosomal recessive type 82 (DFNB82) [MIM:613557]. DFNB82 is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss. There are no symptoms of vestibular dysfunction.
    • 序列相似性
      Belongs to the GPSM family.
      Contains 4 GoLoco domains.
      Contains 8 TPR repeats.
    • 细胞定位
      Cytoplasm. Cytoplasm > cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DFNB82 antibody
      • G protein signalling modulator 2 (AGS3 like C. elegans) antibody
      • G protein signalling modulator 2 antibody
      • G-protein-signaling modulator 2 antibody
      • Gpsm2 antibody
      • GPSM2_HUMAN antibody
      • HGNC:29501 antibody
      • LGN antibody
      • LGN protein antibody
      • Mosaic protein LGN antibody
      • Pins antibody
      see all

    图片

    • Detection of GPSM2 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab110147 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-GPSM2 antibody which recognizes a downstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 30 seconds.

    文献

    ab110147 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab110147.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    注册