Anti-GPSM1抗体(ab111022)

概述

  • 产品名称
  • 描述
    兔多克隆抗体to GPSM1
  • 经测试应用
    适用于: IHC-Fr, WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, a wide range of other species
  • 免疫原

    Synthetic peptide, derived from an internal region of Human GPSM1 (UniProt ID: Q86YR5).

性能

应用

Our Abpromise guarantee covers the use of ab111022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
WB 1/1000 - 1/5000. Predicted molecular weight: 75 kDa.
IHC-P 1/100 - 1/1000.

靶标

  • 功能
    Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
  • 组织特异性
    Expressed in intestinal cells.
  • 序列相似性
    Belongs to the GPSM family.
    Contains 4 GoLoco domains.
    Contains 9 TPR repeats.
  • 结构域
    The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.
  • 翻译后修饰
    Phosphorylation regulates interaction with G(i/o) alpha.
  • 细胞定位
    Cytoplasm > cytosol. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activator of G-protein signaling 3 antibody
    • AGS3 antibody
    • AGS3 homolog antibody
    • C10a antibody
    • G protein signaling modulator 1 (AGS3 like, C. elegans) antibody
    • G-protein-signaling modulator 1 antibody
    • GPSM1 antibody
    • GPSM1_HUMAN antibody
    see all

Anti-GPSM1 antibody (ab111022)参考文献

ab111022 has not yet been referenced specifically in any publications.

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (Mouse Embryo (day 8.5))
Specification
Mouse Embryo (day 8.5)
Fixative
Paraformaldehyde
Blocking step
Serum as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 37°C
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Derek Passer

Verified customer

提交于 Oct 13 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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