概述

  • 产品名称Anti-GPNMB抗体
    参阅全部 GPNMB 一抗
  • 描述
    小鼠单克隆抗体to GPNMB
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human, Recombinant Fragment
  • 免疫原

    Recombinant fragment: RCQKEDANGN IVYEKNCRNE AGLSADPYVY NWTAWSEDSD GENGTGQSHH NVFPDGKPFP HHPGWRRWNF IYVFHTLGQY FQKLGRCSVR VSVNTANVTL , corresponding to amino acids 104-204 of Human GPNMB

性能

应用

Our Abpromise guarantee covers the use of ab56584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
WB
  • 应用说明IHC-P: Use at an assay dependent dilution (PMID 20133820).
    WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Could be a melanogenic enzyme.
    • 组织特异性Not restricted to the melanocytic lineage.
    • 序列相似性Belongs to the PMEL/NMB family.
      Contains 1 PKD domain.
    • 发展阶段Expression in poorly metastatic melanoma cell lines; no expression in highly metastatic melanoma cell lines.
    • 细胞定位Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Glycoprotein (transmembrane) nmb antibody
      • Glycoprotein nmb antibody
      • Glycoprotein nmb like protein antibody
      • Gpnmb antibody
      • GPNMB_HUMAN antibody
      • HGFIN antibody
      • NMB antibody
      • Osteoactivin antibody
      • Transmembrane glycoprotein antibody
      • Transmembrane glycoprotein HGFIN antibody
      • Transmembrane glycoprotein NMB antibody
      see all

    Anti-GPNMB antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56584 GPNMB antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-GPNMB antibody (ab56584)参考文献

    This product has been referenced in:
    • Tyburczy ME  et al. Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications. Am J Pathol 176:1878-90 (2010). IHC-P ; Human . Read more (PubMed: 20133820) »

    See 1 Publication for this product

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    ab56584 has been characterised in Western Blot using thetagged recombinant protein immunogen (37 kDa), not the endogenous protein. Read More

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