概述

  • 产品名称Anti-GPCR TGR5抗体
    参阅全部 GPCR TGR5 一抗
  • 描述
    兔多克隆抗体to GPCR TGR5
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Monkey
  • 免疫原

    A synthetic peptide (LWGRASRDSPGPSIAYHPSSQ) corresponding to amino acids 302-322 of human BG37/TGR5 was used as the immunogen, GenBank no NP_733800.1.

  • 阳性对照
    • Human kidney lysate, human colon tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium azide
    Constituents: PBS, 0.05% BSA
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab71988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明IHC-P: Use at a concentration of 10 µg/ml.
    WB: Use at a concentration of 2 - 4 µg/ml. Detects bands of approximately 33 and 50 kDa (predicted molecular weight: 37 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
    • 组织特异性Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
    • 序列相似性Belongs to the G-protein coupled receptor 1 family.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BG 37 antibody
      • BG37 antibody
      • G protein coupled bile acid receptor 1 antibody
      • G protein coupled bile acid receptor BG 37 antibody
      • G protein coupled bile acid receptor BG37 antibody
      • G-protein coupled bile acid receptor 1 antibody
      • G-protein coupled receptor GPCR19 antibody
      • GPBAR 1 antibody
      • GPBAR_HUMAN antibody
      • GPBAR1 antibody
      • GPCR 19 antibody
      • GPCR antibody
      • GPCR19 antibody
      • GPR 131 antibody
      • GPR131 antibody
      • hBG 37 antibody
      • hBG37 antibody
      • hGPCR 19 antibody
      • hGPCR19 antibody
      • M BAR antibody
      • M-BAR antibody
      • Membrane bile acid receptor antibody
      • Membrane type receptor for bile acids antibody
      • Membrane-type receptor for bile acids antibody
      • MGC40597 antibody
      • TGR 5 antibody
      • TGR5 antibody
      see all

    Anti-GPCR TGR5 antibody 图像

    • All lanes : Anti-GPCR TGR5 antibody (ab71988) at 3 µg/ml

      Lane 1 : human kidney lysate
      Lane 2 : human kidney lysate with immunising peptide


      Predicted band size : 37 kDa
      Observed band size : 33 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 50 kDa. We are unsure as to the identity of these extra bands.
    • ab71988 at 5µg/ml staining GPCR TGR5 in human kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin embedded tissue section). The top left image show staining with the Isotype control antibody, the bottom left and right image show staining with ab71988.

    Anti-GPCR TGR5 antibody (ab71988)参考文献

    This product has been referenced in:
    • Ockenga J  et al. Plasma bile acids are associated with energy expenditure and thyroid function in humans. J Clin Endocrinol Metab 97:535-42 (2012). IHC ; Human . Read more (PubMed: 22162464) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"