概述

  • 产品名称Anti-GPCR GPR37抗体
    参阅全部 GPCR GPR37 一抗
  • 描述
    兔多克隆抗体to GPCR GPR37
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region from the N-terminal extracellular domain of Human GPCR GPR37.

  • 阳性对照
    • Human brain cortex tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Orphan receptor. May have a unique functional role in the central nervous system.
  • 组织特异性Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰Ubiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
  • 细胞定位Cell membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDNRBL antibody
    • Endothelin B receptor like protein 1 antibody
    • Endothelin B receptor-like protein 1 antibody
    • Endothelin receptor type B like antibody
    • ETBR LP 1 antibody
    • ETBR-LP-1 antibody
    • ETBRLP1 antibody
    • G protein coupled receptor 37 antibody
    • G protein coupled receptor 37 endothelin receptor type B like antibody
    • Gpr37 antibody
    • GPR37_HUMAN antibody
    • hET(B)R LP antibody
    • hET(B)RLP antibody
    • PAELR antibody
    • Parkin associated endothelin receptor like receptor antibody
    • Parkin-associated endothelin receptor-like receptor antibody
    • Probable G protein coupled receptor 37 antibody
    • Probable G-protein coupled receptor 37 antibody
    see all

Anti-GPCR GPR37 antibody 图像

  • ab115902, at 3 µg/ml, staining GPCR GPR37 in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-GPCR GPR37 antibody (ab115902)参考文献

ab115902 has not yet been referenced specifically in any publications.

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