Anti-GPCR GPR126抗体(ab117092)

概述

  • 产品名称Anti-GPCR GPR126抗体
    参阅全部 GPCR GPR126 一抗
  • 描述
    兔多克隆抗体to GPCR GPR126
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, from the N terminal domain of Human GPCR GPR126.

  • 阳性对照
    • Human liver and prostate tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab117092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

靶标

  • 功能Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.
  • 组织特异性Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
  • 序列相似性Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 1 CUB domain.
    Contains 1 GPS domain.
    Contains 1 pentaxin domain.
  • 翻译后修饰Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
  • 细胞定位Cell membrane. Detected on the cell surface of activated but not resting umbilical vein.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APG1 antibody
    • Developmentally regulated G-protein-coupled receptor antibody
    • dj287g14.2 antibody
    • DREG antibody
    • G-protein coupled receptor 126 antibody
    • GP126_HUMAN antibody
    • GPR126 antibody
    • HBV PreS1-transactivated protein 2 antibody
    • OTTHUMP00000017320 antibody
    • OTTHUMP00000237093 antibody
    • OTTHUMP00000237094 antibody
    • OTTHUMP00000237115 antibody
    • Probable G-protein coupled receptor 126 [Precursor] antibody
    • Probable G-protein coupled receptor 126 antibody
    • PS1TP2 antibody
    • Vascular inducible G protein-coupled receptor antibody
    • VIGR antibody
    see all

Anti-GPCR GPR126 antibody 图像

  • ab117092 at 10 µg/ml staining GPCR GPR126 in Formalin-Fixed, Paraffin-Embedded Human Liver tissue by Immunohistochemistry.
  • ab117092 at 10 µg/ml staining GPCR GPR126 in Formalin-Fixed, Paraffin-Embedded Human Prostate tissue by Immunohistochemistry.

Anti-GPCR GPR126 antibody (ab117092)参考文献

ab117092 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (Spleen)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: DAKO S169984-2
Permeabilization No
Specification Spleen
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
Fixative Paraformaldehyde
Username

Gentian Musa

Verified customer

提交于 Sep 16 2016

Thank you for contacting Abcam.

Below is a link that will give you a general antigen retrieval protocol, you may have to modify it to suit your own needs, but it will provide a good starting point:

http://ihcworld.com/_protocols/epi...

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Thank you for this feedback. I am sorry that I could not be of more help on this occasion. If you like to get some more information on our testing discount program, please find the Terms and Conditions of this offer at: www.abcam.com/collabora...

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Thank you for contacting us. I am happy to let you know the following immunogen sequences: ab65175: xxxxxxxxxxxxxxxxxx ab75356: yyyyyyyyyyyyyyyy In preliminary searches, I could not find conclusive matches for these peptides in zebrafish (onl...

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