Anti-GPCR GPR120抗体(ab118757)

概述

  • 产品名称
    Anti-GPCR GPR120抗体
    参阅全部 GPCR GPR120 一抗
  • 描述
    兔多克隆抗体to GPCR GPR120
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 243-292 (VVTHSEITKA SRKRLTVSLA YSESHQIRVS QQDFRLFRTL FLLMVSFFIM) of Human GPCR GPR120.

  • 阳性对照
    • HepG2 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab118757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
  • 组织特异性
    Abundant expression in the intestinal tract.
  • 序列相似性
    Belongs to the G-protein coupled receptor 1 family.
  • 翻译后修饰
    Phosphorylated. FFA stimulation facilitates phosphorylation.
  • 细胞定位
    Cell membrane. Colocalized with ARRB2 following DHA treatment.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BMIQ10 antibody
    • FFAR4 antibody
    • Free fatty acid receptor 4 antibody
    • G protein coupled receptor 120 antibody
    • G protein coupled receptor 129 antibody
    • G protein coupled receptor GT01 antibody
    • G protein coupled receptor PGR 4 antibody
    • G protein coupled receptor PGR4 antibody
    • G-protein coupled receptor 120 antibody
    • G-protein coupled receptor 129 antibody
    • G-protein coupled receptor GT01 antibody
    • G-protein coupled receptor PGR4 antibody
    • GPR 120 antibody
    • GPR 129 antibody
    • GPR120 antibody
    • GPR129 antibody
    • GT01 antibody
    • HGNC:19345 antibody
    • MGC119984 antibody
    • O3FA1_HUMAN antibody
    • O3FAR1 antibody
    • Omega-3 fatty acid receptor 1 antibody
    • PGR 4 antibody
    • PGR4 antibody
    see all

图片

  • Anti-GPCR GPR120 antibody (ab118757) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 42 kDa

实验方案

文献

ab118757 has not yet been referenced specifically in any publications.

客户评价及客户问答

Application
Western blot
Sample
Rat Tissue lysate - whole (rat pituitary, mouse LbT2 cell line)
Gel Running Conditions
Non-reduced Denaturing (10%)
Loading amount
30 µg
Specification
rat pituitary, mouse LbT2 cell line
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 6% · Temperature: 20°C
Username

Abcam user community

Verified customer

提交于 May 20 2015

Application
Western blot
Sample
Mouse Cell lysate - whole cell (LbetaT2 gonadotrope cell line)
Gel Running Conditions
Non-reduced Denaturing (10% SDS-PAGE)
Loading amount
30 µg
Specification
LbetaT2 gonadotrope cell line
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 6% · Temperature: 20°C
Username

Abcam user community

Verified customer

提交于 May 20 2015

Vielen Dank für Ihre Antwort.
Wie besprochen wurde ab118757 bisher noch nicht in Maus getestet.
Falls Sie dies selbst testen möchten, kann ich Ihnen zurzeit ein spezielles Angebot über einen 100%igen Abreview-Rabatt anbieten. Bei diesem Angeb...

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Vielen Dank für das Telefongespräch gestern.
Ich möchte nochmals betonen wie leid es uns tut, dass ab75313 nicht in der von Ihnen gewünschten Menge lieferbar ist.
Leider haben wir keinen anderen GPCR GPR120 Antikörper, der für Maus getestet i...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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