概述

  • 产品名称Anti-gp340抗体
    参阅全部 gp340 一抗
  • 描述
    兔多克隆抗体to gp340
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 467-516 (SWSTPSPDTL PTITLPASTV GSESSLALRL VNGGDRCQGR VEVLYRGSWG) of Human gp340 (NP_015568).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99175 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 261 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.
  • 组织特异性Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.
  • 疾病相关Defects in DMBT1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
  • 序列相似性Belongs to the DMBT1 family.
    Contains 2 CUB domains.
    Contains 14 SRCR domains.
    Contains 1 ZP domain.
  • 发展阶段Expressed in fetal lung, intestine and skin. Secreted to the extracellular matrix (ECM) in certain fetal epithelia.
  • 结构域The SRCR domains mediate binding to bacteria. The minimal bacterial-binding site is an 11-residue repeat of GRVEVLYRGSW where VEVL and W are critical residues.
  • 翻译后修饰Highly N- and O-glycosylated. The O-glycans are heavily sulfated.
  • 细胞定位Secreted. Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apactin antibody
    • CRP antibody
    • CRP-[a] antibody
    • CRP-[b] antibody
    • CRP-ductin antibody
    • Crpd antibody
    • DBMT1 antibody
    • Deleted in malignant brain tumors 1 antibody
    • Deleted in malignant brain tumors 1 protein antibody
    • DMBT 1 antibody
    • DMBT1 antibody
    • DMBT1 prototype precursor antibody
    • DMBT1/6kb.1 protein precursor antibody
    • DMBT1/8kb.1 protein antibody
    • DMBT1/8kb.2 protein precursor antibody
    • DMBT1_HUMAN antibody
    • Ebnerin antibody
    • FLJ61058 antibody
    • Glycoprotein 300 antibody
    • Glycoprotein 340 antibody
    • Gp 340 antibody
    • Gp-340 antibody
    • gp300 antibody
    • GP340 antibody
    • Gp340 variant protein antibody
    • Hensin antibody
    • MGC164738 antibody
    • Mucin-like glycoprotein antibody
    • Muclin antibody
    • OTTHUMP00000020654 antibody
    • OTTHUMP00000020655 antibody
    • OTTHUMP00000020656 antibody
    • OTTHUMP00000020657 antibody
    • OTTHUMP00000020658 antibody
    • OTTHUMP00000020659 antibody
    • OTTHUMP00000020660 antibody
    • OTTHUMP00000020661 antibody
    • OTTHUMP00000020662 antibody
    • OTTHUMP00000020663 antibody
    • p80 antibody
    • Pancrin antibody
    • SAG antibody
    • Salivary agglutinin antibody
    • Surfactant pulmonary associated D binding protein antibody
    • Surfactant pulmonary associated protein D binding protein antibody
    • Surfactant pulmonary-associated D-binding protein antibody
    • Vomeroglandin antibody
    see all

Anti-gp340 antibody 图像



  • Predicted band size : 261 kDa
    Western blot analysis of Human stomach tissue lysate labeling gp340 with ab99175 at 1µg/ml.


  • Predicted band size : 261 kDa
    Western blot analysis of MCF7-DMBT1+Dox (lane 1) MCF7-DMBT1 -Dox (lane 2) MCF7-Ctrl+Dox (lane 3) MCF7-DMBT1 -Dox (lane 4) cell lysates (2µg/lane) labeling gp340 with ab99175 at 1:5000. A HRP-conjugated anti-rabbit (1:10000) was used as the secondary antibody.

Anti-gp340 antibody (ab99175)参考文献

ab99175 has not yet been referenced specifically in any publications.

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