The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
A gonadotropin-releasing hormone agonist (GnRHa) is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with its receptor to elicit its biological response, the release of the pituitary hormones FSH and LH. Agonists do not quickly dissociate from the GnRH receptor. As a result, there is an initial increase in FSH and LH secretion (so-called flare effect).
GnRH agonists are synthetically modeled after the natural GnRH decapeptide with specific amino acid substitutions typically in positions 6 and 10. These substitutions inhibit rapid degradation. Agonists with two substitutions include: leuprolide, buserelin, nafarelin, historelin, goserelin and deslorelin.
GnRH antagonist antibody
Gonadotropin releasing hormone agonist antibody
Anti-GnRHa antibody (ab45068)参考文献
has not yet been referenced specifically in any publications.