概述

  • 产品名称Anti-GM2A抗体
    参阅全部 GM2A 一抗
  • 描述
    兔多克隆抗体to GM2A
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, from the N-terminal region of Human GM2A (NP_000396.2).

  • 阳性对照
    • Human kidney and skin tissues.

性能

应用

Our Abpromise guarantee covers the use of ab118433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 - 12.5 µg/ml.

靶标

  • 功能Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • 疾病相关Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • 翻译后修饰The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Anti-GM2A antibody 图像

  • ab118433 at 12.5µg/ml staining GM2A in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab118433 at 12.5µg/ml staining GM2A in Formalin-fixed, Paraffin-embedded Human skin tissue by Immunohistochemistry.

Anti-GM2A antibody (ab118433)参考文献

ab118433 has not yet been referenced specifically in any publications.

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