概述

  • 产品名称Anti-GM2A抗体
    参阅全部 GM2A 一抗
  • 描述
    山羊多克隆抗体to GM2A
  • 特异性ab113440 is expected to recognize isoform 1 (NP_000396.2) only.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Rabbit
  • 免疫原

    Synthetic peptide:

    C-TTGNYRIESVLS

    , corresponding to internal sequence amino acids 164-175 of Human GM2A (NP_000396.2).

  • 阳性对照
    • HEK293 lysate overexpressing Human GM2A with DYKDDDDK tag, Mock-transfected HEK293 lysate

性能

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应用

Our Abpromise guarantee covers the use of ab113440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 21 kDa).

靶标

  • 功能Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • 疾病相关Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • 翻译后修饰The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Anti-GM2A antibody 图像

  • Anti-GM2A antibody (ab113440) at 0.300000011921 µg/ml + Rat kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 21 kDa
  • Lane 1 : Anti-GM2A antibody (ab113440) at 1 µg/ml
    Lane 2 : Anti-GM2A antibody (ab113440) at 1 mg/ml
    Lane 3 : anti- DYKDDDDK Tag at 1/30000 dilution

    Lane 1 : HEK293 lysate (in RIPA buffer) overexpressing Human GM2A with DYKDDDDK tag
    Lane 2 : Mock-transfected HEK293 lysate (in RIPA buffer)
    Lane 3 : HEK293 lysate (in RIPA buffer) overexpressing Human GM2A with DYKDDDDK tag

    Lysates/proteins at 10 µg per lane.

    Developed using the ECL technique

    Predicted band size : 21 kDa

Anti-GM2A antibody (ab113440)参考文献

ab113440 has not yet been referenced specifically in any publications.

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