概述

  • 产品名称Anti-GM2A抗体
    参阅全部 GM2A 一抗
  • 描述
    兔多克隆抗体to GM2A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal amino acids 32-62 of Human GM2A (NP_000396.2).

  • 阳性对照
    • A2058 cell lysate, Mouse liver tissue lysate.

性能

应用

Our Abpromise guarantee covers the use of ab107501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 21 kDa.

靶标

  • 功能Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • 疾病相关Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • 翻译后修饰The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Anti-GM2A antibody 图像

  • Anti-GM2A antibody (ab107501) at 1/100 dilution + A2058 cell lysate at 35 µg

    Predicted band size : 21 kDa
  • Anti-GM2A antibody (ab107501) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 21 kDa

Anti-GM2A antibody (ab107501)参考文献

ab107501 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab107501.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"