Anti-GM-CSF Receptor alpha抗体[4H1] (FITC) (ab95684)

概述

  • 产品名称Anti-GM-CSF Receptor alpha抗体[4H1] (FITC)
    参阅全部 GM-CSF Receptor alpha 一抗
  • 描述
    小鼠单克隆抗体[4H1] to GM-CSF Receptor alpha (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human GM-CSF Receptor alpha transfected COS cells.

  • 阳性对照
    • Normal human peripheral blood cells/leukocytes.

性能

应用

Our Abpromise guarantee covers the use of ab95684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 5µl for 106 cells.

ab106163 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • 疾病相关Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD_antigen=CD116 antibody
    • CD116 antibody
    • CD116 antigen antibody
    • CDw116 antibody
    • Colony stimulating factor 2 receptor alpha chain antibody
    • Colony stimulating factor 2 receptor alpha low affinity antibody
    • Colony stimulating factor 2 receptor alpha subunit antibody
    • CSF 2R antibody
    • CSF2R antibody
    • CSF2R_HUMAN antibody
    • CSF2RA antibody
    • CSF2RAX antibody
    • CSF2RAY antibody
    • CSF2RX antibody
    • CSF2RY antibody
    • GM CSF R alpha antibody
    • GM CSF receptor alpha subunit antibody
    • GM-CSF-R-alpha antibody
    • GMCSFR antibody
    • GMCSFR-alpha antibody
    • GMR-alpha antibody
    • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
    • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
    • SMDP4 antibody
    see all

Anti-GM-CSF Receptor alpha antibody [4H1] (FITC) 图像

  • Flow cytometry staining of normal Human peripheral blood cells with Mouse IgG1 ? Isotype Control FITC (open histogram) or 20µl ab95684 (filled histogram). Cells in the monocyte gate were used for analysis.

Anti-GM-CSF Receptor alpha antibody [4H1] (FITC) (ab95684)参考文献

ab95684 has not yet been referenced specifically in any publications.

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