Anti-GM-CSF Receptor alpha抗体[4H1] (ab95681)

概述

  • 产品名称Anti-GM-CSF Receptor alpha抗体[4H1]
    参阅全部 GM-CSF Receptor alpha 一抗
  • 描述
    小鼠单克隆抗体[4H1] to GM-CSF Receptor alpha
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human GM-CSF Receptor alpha transfected COS cells.

  • 阳性对照
    • Human peripheral blood leukocytes

性能

应用

Our Abpromise guarantee covers the use of ab95681 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 105 cells. Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).



ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
  • 疾病相关Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD_antigen=CD116 antibody
    • CD116 antibody
    • CD116 antigen antibody
    • CDw116 antibody
    • Colony stimulating factor 2 receptor alpha chain antibody
    • Colony stimulating factor 2 receptor alpha low affinity antibody
    • Colony stimulating factor 2 receptor alpha subunit antibody
    • CSF 2R antibody
    • CSF2R antibody
    • CSF2R_HUMAN antibody
    • CSF2RA antibody
    • CSF2RAX antibody
    • CSF2RAY antibody
    • CSF2RX antibody
    • CSF2RY antibody
    • GM CSF R alpha antibody
    • GM CSF receptor alpha subunit antibody
    • GM-CSF-R-alpha antibody
    • GMCSFR antibody
    • GMCSFR-alpha antibody
    • GMR-alpha antibody
    • Granulocyte macrophage colony stimulating factor receptor alpha chain antibody
    • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody
    • SMDP4 antibody
    see all

Anti-GM-CSF Receptor alpha antibody [4H1] (ab95681)参考文献

ab95681 has not yet been referenced specifically in any publications.

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