概述

  • 产品名称GM 6001
  • 描述
    Broad spectrum MMP inhibitor
  • 别名
    • Galardin
    • ilomastat
  • 生物学描述

    Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

  • 纯度> 98%

性能

  • 化学名称(2R)-N4-Hydroxy-N1-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
  • 分子量388.47
  • 化学结构Chemical Structure
  • 分子式C20H28N4O4
  • CAS编号142880-36-2
  • PubChem识别号132519
  • 存放说明Store at +4°C. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 100 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc1ccccc12)C(=O)NC
  • 来源

    Synthetic

    GM 6001 (ab120845)参考文献

    This product has been referenced in:
    • Zhang H  et al. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20 (2011). Read more (PubMed: 21455784) »
    • Levy DE  et al. Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998). Read more (PubMed: 9457244) »
    • Grobelny D  et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31:7152-4 (1992). Read more (PubMed: 1322694) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"