概述

  • 产品名称
    Anti-Glypican 6抗体
    参阅全部 Glypican 6 一抗
  • 描述
    兔多克隆抗体to Glypican 6
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide selected from the N terminal region of human Glypican 6, conjugated to KLH

  • 阳性对照
    • K562 cell line lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Ammonium Sulphate Precipitation
  • 纯化说明
    ab71343 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab71343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).

靶标

  • 功能
    Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.
  • 组织特异性
    Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).
  • 疾病相关
    Defects in GPC6 are a cause of omodysplasia type 1 (OMOD1) [MIM:258315]. OMOD1 is a rare autosomal recessive skeletal dysplasia characterized by severe congenital micromelia with shortening and distal tapering of the humeri and femora to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. Note=Point mutations leading to protein truncation, as well as larger genomic rearrangements resulting in exon deletions, have been found in family segregating omodysplasia type 1. All mutations identified in individuals affected by omodysplasia could lead to the absence of a functional protein, the mutant RNAs being suspected to be nonsense-mediated mRNA decay (NMD) targets. Even if the mRNA escapes NMD and is translated, all mutations are expected to disrupt the three-dimensional protein structure and often to abolish multiple highly conserved cysteine residues.
  • 序列相似性
    Belongs to the glypican family.
  • 细胞定位
    Cell membrane and Secreted > extracellular space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GPC 6 antibody
    • Glypican 6 [Precursor] antibody
    • Glypican proteoglycan 6 antibody
    • Gpc6 antibody
    • GPC6_HUMAN antibody
    • MGC126288 antibody
    • OMIMD1 antibody
    • PRO705 antibody
    • Secreted glypican 6 antibody
    • Secreted glypican-6 antibody
    • UNQ369 antibody
    see all

Anti-Glypican 6 antibody 图像

  • Anti-Glypican 6 antibody (ab71343) at 1/60 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 63 kDa
    Observed band size : 63 kDa

实验方案

Anti-Glypican 6 antibody (ab71343)参考文献

ab71343 has not yet been referenced specifically in any publications.

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