概述

  • 产品名称Anti-Glypican 3抗体
    参阅全部 Glypican 3 一抗
  • 描述
    羊多克隆抗体to Glypican 3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant protein corresponding to C terminal Human Glypican 3 (~70aa).

  • 阳性对照
    • Human hepatocellular carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab81263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 5 - 10 µg/ml. Predicted molecular weight: 66 kDa.
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
  • 组织特异性Highly expressed in lung, liver and kidney.
  • 疾病相关Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
  • 序列相似性Belongs to the glypican family.
  • 细胞定位Cell membrane and Secreted > extracellular space.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DGSX antibody
    • Glypican proteoglycan 3 antibody
    • Glypican-3 [Precursor] antibody
    • Gpc3 antibody
    • GPC3_HUMAN antibody
    • GTR2 2 antibody
    • GTR2-2 antibody
    • Heparan sulphate proteoglycan antibody
    • Intestinal protein OCI 5 antibody
    • Intestinal protein OCI-5 antibody
    • MXR7 antibody
    • OCI 5 antibody
    • OCI-5 antibody
    • OCI5 antibody
    • SDYS antibody
    • Secreted glypican-3 antibody
    • SGB antibody
    • SGBS antibody
    • SGBS1 antibody
    see all

Anti-Glypican 3 antibody 图像

  • ab81263, at 10ug/ml, staining human hepatocellular carcinoma tissue by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Secondary antibody, HRP conjugated mouse antisheep used at 1:20 dilution. Sections heated for 10 minutes with 10 mM sodium citrate.

Anti-Glypican 3 antibody (ab81263)参考文献

ab81263 has not yet been referenced specifically in any publications.

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