Recombinant fragment: VLSAAMQGDV KSMAQFYGLL AHVARTRLTP SMAGASVEED AQLHELAAEL QIPDLQLEEA LETMAWGRGP VCLLAGGEPT VQLQGSGRGG RNQELALRV, corresponding to amino acids 332-430 of human GLYCTK (NP_660305) with a 26 kDa tag
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.
Use at an assay dependent dilution.
疾病相关Defects in GLYCTK are the cause of D-glyceric aciduria (D-GA) [MIM:220120]. D-GA is a rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development.
序列相似性Belongs to the glycerate kinase type-2 family.