Anti-Glycoprotein VI抗体(ab82807)

概述

  • 产品名称Anti-Glycoprotein VI抗体
    参阅全部 Glycoprotein VI 一抗
  • 描述
    兔多克隆抗体to Glycoprotein VI
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY) of Human GP6 (NP_057447).

  • 阳性对照
    • Jurkat cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab82807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

靶标

  • 功能Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
  • 组织特异性Megakaryocytes and platelets.
  • 疾病相关Bleeding disorder, platelet-type 11
  • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Glycoprotein 6 antibody
    • Glycoprotein VI antibody
    • GP6 antibody
    • GPIV antibody
    • GPVI antibody
    • GPVI_HUMAN antibody
    • MGC138168 antibody
    • Platelet collagen receptor antibody
    • Platelet glycoprotein VI antibody
    • Platelet glycoprotein VI precursor antibody
    see all

Anti-Glycoprotein VI antibody 图像

  • Anti-Glycoprotein VI antibody (ab82807) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
    Additional bands at : 80 kDa. We are unsure as to the identity of these extra bands.

Anti-Glycoprotein VI antibody (ab82807)参考文献

ab82807 has not yet been referenced specifically in any publications.

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