Glycophorin A肽(139-150) (ab45821)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列SVEIENPETSDQ
    • 氨基酸139 to 150

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Glycophorin A antibody (ab40844)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • AI853584
    • Blood group--MN locus
    • CD_antigen=CD235a
    • CD235a
    • GLPA_HUMAN
    • Glycophorin A
    • Glycophorin A (MNS blood group)
    • Glycophorin A, included
    • Glycophorin-A
    • GlycophorinA
    • GPA
    • GPErik
    • GpMiIII
    • GPSAT
    • GYPA
    • GYPA, included
    • HGpMiIII
    • HGpMiV
    • HGpMiX
    • HGpMiXI
    • HGpSta(C)
    • MN
    • MN sialoglycoprotein
    • MNS
    • PAS-2
    • PAS2
    • Sialoglycoprotein alpha
    see all
  • 功能Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
  • 序列相似性Belongs to the glycophorin A family.
  • 翻译后修饰The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNacOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
  • 细胞定位Cell membrane. Appears to be colocalized with SLC4A1.
  • Information by UniProt

Glycophorin A peptide (139-150) (ab45821)参考文献

ab45821 has not yet been referenced specifically in any publications.

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