Anti-Glycogen synthase 1 (phospho S645)抗体(ab53691)

概述

  • 产品名称Anti-Glycogen synthase 1 (phospho S645)抗体
    参阅全部 Glycogen synthase 1 一抗
  • 描述
    兔多克隆抗体to Glycogen synthase 1 (phospho S645)
  • 特异性ab53691 detects endogenous levels of Glycogen Synthase only when phosphorylated at serine 645.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic phosphopeptide derived from human Glycogen Synthase around the phosphorylation site of serine 645 (P-P-SP-P-S).

  • 阳性对照
    • Human skeletal muscle tissue.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab53691 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
IHC-P 1/5.

靶标

  • 功能Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • 通路Glycan biosynthesis; glycogen biosynthesis.
  • 疾病相关Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also known as muscle glycogen synthase deficiency. GSD0b is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
  • 序列相似性Belongs to the glycosyltransferase 3 family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Glycogen [starch] synthase antibody
    • Glycogen synthase 1 (muscle) antibody
    • Glycogen synthase 1 antibody
    • GSY antibody
    • GYS antibody
    • Gys1 antibody
    • GYS1_HUMAN antibody
    • muscle antibody
    see all

Anti-Glycogen synthase 1 (phospho S645) antibody 图像

  • ab53691 at 1/50 dilution staining Glycogen Synthase 1 in human skeletal muscle by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.
  • IHC image of ab53691 staining in human normal skeletal muscle formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab53691, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Glycogen synthase 1 (phospho S645) antibody (ab53691)参考文献

ab53691 has not yet been referenced specifically in any publications.

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