Anti-Glutathione抗体(ab37124)

概述

  • 产品名称Anti-Glutathione抗体
    参阅全部 Glutathione 一抗
  • 描述
    大鼠多克隆抗体to Glutathione
  • 特异性ab37124 targets conjugated glutathione, it doesn't recognize free glutathione.
  • 经测试应用适用于: IHC-Pmore details
  • 免疫原

    Chemical/ Small Molecule corresponding to Glutathione conjugated to Bovine Serum Albumin (BSA) (Glutaraldehyde).

性能

应用

Our Abpromise guarantee covers the use of ab37124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.

Fixation of tissue for use with these antibodies should be done with gluteraldehyde. The use of paraformaldehyde in conjunction with gluteraldehyde may improve staining results.

靶标

  • 相关性Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form. Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.
  • 别名
    • Glutathione antibody
    • GSH antibody
    • Oxidised glutathione antibody
    • Reduced glutathione antibody

Anti-Glutathione antibody (ab37124)参考文献

ab37124 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. The following publication shows glutathione (GSH) expression in frozen sections from various tissues including liver, lung, kidney, testis and eye (Fig. 3 & 4). HISTOCHEMICAL LOCALIZATION OF GLUTATHIONE IN TISSUES. T...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"