Anti-Glutamine Synthetase抗体(ab6585)


  • 产品名称Anti-Glutamine Synthetase抗体
    参阅全部 Glutamine Synthetase 一抗
  • 描述
    山羊多克隆抗体to Glutamine Synthetase
  • 经测试应用适用于: WB, IP, ELISA, Dot blotmore details
  • 种属反应性
    与反应: Escherichia coli
  • 免疫原

    Glutamine Synthetase [Microbial]


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液0.02M K Phosphate, 0.15M NaCl, 0.01% Sodium Azide, pH7.2
  • 纯度Whole antiserum
  • 纯化说明This product was prepared from monospecific antiserum by a delipidation and defibrination. Assay by immunoelectrophoresis resulted in a single precipitin arc against purified and partially purified Glutamine Synthetase [Microbial].
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab6585 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Dot blot
  • 应用说明immunoblotting (western or dot blot), ELISA (1:10,000 to 1:40,000), immunoprecipitation and most immunological methods requiring high titer and specificity.
  • 靶标

    • 功能This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
    • 疾病相关Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
    • 序列相似性Belongs to the glutamine synthetase family.
    • 发展阶段Expressed during early fetal stages.
    • 细胞定位Cytoplasm. Mitochondrion.
    • Information by UniProt
    • 别名
      • cell proliferation-inducing protein 59 antibody
      • GLNA antibody
      • GLNA_HUMAN antibody
      • GLNS antibody
      • GLUL antibody
      • Glutamate ammonia ligase antibody
      • Glutamate decarboxylase antibody
      • Glutamate--ammonia ligase antibody
      • glutamine synthase antibody
      • Glutamine synthetase antibody
      • GS antibody
      • PIG 43 antibody
      • PIG 59 antibody
      • PIG43 antibody
      • PIG59 antibody
      • Proliferation inducing protein 43 antibody
      see all

    Anti-Glutamine Synthetase antibody (ab6585)参考文献

    This product has been referenced in:
    • Ivanovska N & Dimitrova P Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine. Arthritis Res Ther 13:R44 (2011). IHC-P ; Mouse . Read more (PubMed: 21410959) »
    • Yuan J  et al. Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol Syst Biol 5:302 (2009). WB ; Escherichia coli . Read more (PubMed: 19690571) »

    See all 2 Publications for this product

    Product Wall

    They have informed me that for both ab6585 and ab34525, they do not have any data on possible cross-reactivity with Streptomyces lincolnensis. The actual immunogen is not sequenced but a reference sequence for comparison is shown at: http://www.un...

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    I suggest that you conduct your search as normal through the Abcam Website. As you cannot find a product within the Abcam catalog that meets your needs, click on the link to "The World's Antibody Gateway". The World's Antibody Gateway is a free search ...

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    I've checked our previous enquiries for this antibody and it seems that there are lots of questions regarding the nature of the immunogen, but I'm afraid that I do not know from which microbe the GS was derived. The antibody has not specifically been t...

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    We have contacted the manufacturer of the enzyme used, and they can't tell us which isoform of Gln synthetase was used. Apparently, they measure activity in a set assay and if the enzyme (or enzymes) perform properly, they don't worry about which isofo...

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    This antibody was raised against a microbial glutamine synthetase and has not been specifically tested for cross-reactivity with the rat enzyme. Neither has it been used previously in immunocytochemistry, however it is thought likely that it would work...

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    This antibody has been raised against microbial glutamine synthetase and does not react with the mouse protein.

    This antibody has not been specifically tested in IHC and IF. Unfortunately, we do not know of any references where this antibody has been used.