Anti-Glutamine Synthetase抗体(ab49873)
Key features and details
- Rabbit polyclonal to Glutamine Synthetase
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Glutamine Synthetase抗体
参阅全部 Glutamine Synthetase 一抗 -
描述
兔多克隆抗体to Glutamine Synthetase -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Chicken, Hamster, Cow, Dog, Human, Pig, Cynomolgus monkey -
免疫原
Synthetic peptide corresponding to Mouse Glutamine Synthetase aa 357-373 (C terminal).
Sequence:RTCLLNETGDEPFQYKN
Database link: P09606 -
阳性对照
- WB: Rat brain whole extract.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading...
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纯度
Ion Exchange Chromatography -
纯化说明
Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab49873于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/10000. Predicted molecular weight: 42 kDa.
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说明 |
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WB
1/10000. Predicted molecular weight: 42 kDa. |
靶标
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功能
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. -
疾病相关
Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. -
序列相似性
Belongs to the glutamine synthetase family. -
发展阶段
Expressed during early fetal stages. -
细胞定位
Cytoplasm. Mitochondrion. - Information by UniProt
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数据库链接
- Entrez Gene: 396489 Chicken
- Entrez Gene: 281199 Cow
- Entrez Gene: 2752 Human
- Entrez Gene: 396944 Pig
- Entrez Gene: 24957 Rat
- Omim: 138290 Human
- SwissProt: P16580 Chicken
- SwissProt: P15103 Cow
see all -
别名
- cell proliferation-inducing protein 59 antibody
- Cgl2214 antibody
- GLNA antibody
see all
图片
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Lane 1 : Anti-Glutamine Synthetase antibody (ab49873) at 1/5000 dilution
Lane 2 : Anti-Glutamine Synthetase antibody (ab49873) at 1/10000 dilution
Lane 3 : Anti-Glutamine Synthetase antibody (ab49873) at 1/20000 dilution
All lanes : Rat brain whole extract
Secondary
All lanes : Goat Anti-Rabbit IgG-Peroxidase
Predicted band size: 42 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (65)
ab49873 被引用在 65 文献中.
- Han B et al. Fat-associated lymphoid clusters as expandable niches for ectopic liver development. Hepatology 76:357-371 (2022). PubMed: 34890068
- Paul A et al. Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites. Nat Commun 13:930 (2022). PubMed: 35177623
- Wei W et al. SIRT4 Is Highly Expressed in Retinal Müller Glial Cells. Front Neurosci 16:840443 (2022). PubMed: 35185463
- Zhu S et al. Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling. Cell Mol Gastroenterol Hepatol 13:1757-1783 (2022). PubMed: 35202885
- Gutiérrez J et al. Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing. Cell Biosci 12:84 (2022). PubMed: 35672775