Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836)抗体(ab119397)
Key features and details
- Rabbit polyclonal to Glutamate Receptor 1 (AMPA subtype) (phospho S836)
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836)抗体
参阅全部 Glutamate Receptor 1 (AMPA subtype) 一抗 -
描述
兔多克隆抗体to Glutamate Receptor 1 (AMPA subtype) (phospho S836) -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Mouse Brain extracts
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
(without Mg2+ and Ca2+) -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab119397 was affinity-purified by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab119397于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 102 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 102 kDa). |
靶标
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功能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. -
组织特异性
Widely expressed in brain. -
序列相似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. -
翻译后修饰
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. -
细胞定位
Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2 promotes cell surface expression. - Information by UniProt
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数据库链接
- Entrez Gene: 14799 Mouse
- SwissProt: P23818 Mouse
- Unigene: 4920 Mouse
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别名
- GLUR 1 antibody
- GLUR A antibody
- AMPA 1 antibody
see all
图片
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All lanes : Anti-Glutamate Receptor 1 (AMPA subtype) (phospho S836) antibody (ab119397) at 1/500 dilution
Lane 1 : Control
Lane 2 : Mouse Brain extract
Predicted band size: 102 kDa
Observed band size: 106 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab119397 被引用在 1 文献中.
- Thomas R et al. Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice. Heliyon 3:e00319 (2017). ELISA ; Mouse . PubMed: 28626809