Anti-Glucose Transporter GLUT1抗体(ab53767)

概述

  • 产品名称Anti-Glucose Transporter GLUT1抗体
    参阅全部 Glucose Transporter GLUT1 一抗
  • 描述
    兔多克隆抗体to Glucose Transporter GLUT1
  • 特异性This antibody detects endogenous levels of total Glucose Transporter GLUT1 protein
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic Glucose Transporter GLUT1 peptide (Human)

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab53767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 55 kDa.
IHC-P Use at an assay dependent concentration.
ELISA 1/40000.

靶标

  • 功能Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
  • 组织特异性Expressed at variable levels in many human tissues.
  • 疾病相关Defects in SLC2A1 are the cause of glucose transporter type 1 deficiency syndrome (GLUT1DS) [MIM:606777]; also known as blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
    Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.
  • 序列相似性Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cell membrane. Melanosome. Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody
    • CSE antibody
    • DYT17 antibody
    • DYT18 antibody
    • DYT9 antibody
    • EIG12 antibody
    • erythrocyte/brain antibody
    • Erythrocyte/hepatoma glucose transporter antibody
    • facilitated glucose transporter member 1 antibody
    • Glucose transporter 1 antibody
    • Glucose transporter type 1 antibody
    • Glucose transporter type 1, erythrocyte/brain antibody
    • GLUT antibody
    • GLUT-1 antibody
    • GLUT1 antibody
    • GLUT1DS antibody
    • GLUTB antibody
    • GT1 antibody
    • GTG1 antibody
    • Gtg3 antibody
    • GTR1_HUMAN antibody
    • HepG2 glucose transporter antibody
    • HTLVR antibody
    • Human T cell leukemia virus (I and II) receptor antibody
    • MGC141895 antibody
    • MGC141896 antibody
    • PED antibody
    • RATGTG1 antibody
    • Receptor for HTLV 1 and HTLV 2 antibody
    • SLC2A1 antibody
    • Solute carrier family 2 (facilitated glucose transporter), member 1 antibody
    • Solute carrier family 2 antibody
    • Solute carrier family 2, facilitated glucose transporter member 1 antibody
    see all

Anti-Glucose Transporter GLUT1 antibody 图像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab53767 at a 1/50 dilution.

    Left image un-treated.

    Right image treated with peptide.

Anti-Glucose Transporter GLUT1 antibody (ab53767)参考文献

This product has been referenced in:
  • Krockenberger M  et al. Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer. Anticancer Res 30:1653-9 (2010). Read more (PubMed: 20592357) »

See 1 Publication for this product

Product Wall

Thank you for getting back to me and for letting me know about the results.

I am glad to hear that the new antibody works, but I'm sorry that it is very weak. Did you manage to get a good signal despite this, or would you like any assistance ...

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Thank you for providing your protocol information. This will be very helpful for our quality investigation into this antibody. Please let me know how the new antibody is working for you.

Thanks so much for your reply.

I'm sending a free of charge vial of ab53767 on the order ***. This antibody is currently back-ordered until next week, but I expect it to arrive around Friday March 9 or Monday the 12th. Please keep me updated ...

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Thank you for your call yesterday and for your patience.

I have heard back from the lab about our Glut1 antibodies, and the immunogen of ab53767 does not include amino acid 490, so this might be suitable for you. The immunogen is taken from t...

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Thank you for your email.

I am sorry, "Antigen retrieval was done by boiling in citrate buffer pH6 for 30 min" does not reveal information, we are looking for. We are interested in knowing whether microwave, pressure cooker or water...

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Thank you for your enquiry regarding ab53767 and ab104622 and for taking the time to provide some useful details of the experiments. I am very sorry to hear that you are having problems with this antibody.

The protocol looks fine to me howeve...

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