Anti-Glucose 6 phosphate isomerase抗体(ab110051)

概述

  • 产品名称Anti-Glucose 6 phosphate isomerase抗体
    参阅全部 Glucose 6 phosphate isomerase 一抗
  • 描述
    山羊多克隆抗体to Glucose 6 phosphate isomerase
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide (

    C-YREHRSELNLRR

    ) corresponding to internal sequence amino acids 17-28 of Human Glucose 6 phosphate isomerase.

  • 阳性对照
    • Human Kidney, Testis and Thyroid tissue. Human Heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab110051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/128000.
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 63 kDa).
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
  • 通路Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
  • 疾病相关Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
  • 序列相似性Belongs to the GPI family.
  • 翻译后修饰Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
    ISGylated.
  • 细胞定位Cytoplasm. Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AMF antibody
    • Aurocrine motility factor antibody
    • Autocrine motility factor antibody
    • DKFZp686C13233 antibody
    • EC 5.3.1.9 antibody
    • G6PI_HUMAN antibody
    • Glucose phosphate isomerase antibody
    • Glucose-6-phosphate isomerase antibody
    • GNPI antibody
    • GPI antibody
    • Gpi1 antibody
    • Hexose monophosphate isomerase antibody
    • Hexosephosphate isomerase antibody
    • Neuroleukin antibody
    • NLK antibody
    • Oxoisomerase antibody
    • PGI antibody
    • PHI antibody
    • Phosphoglucose isomerase antibody
    • Phosphohexomutase antibody
    • Phosphohexose isomerase antibody
    • Phosphosaccharomutase antibody
    • SA 36 antibody
    • SA-36 antibody
    • SA36 antibody
    • Sperm antigen 36 antibody
    see all

Anti-Glucose 6 phosphate isomerase antibody 图像

  • Anti-Glucose 6 phosphate isomerase antibody (ab110051) at 0.01 µg/ml + Human Heart lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 63 kDa
  • ab110051 at 3.75 µg/ml staining Glucose 6 phosphate isomerase in Formalin-Fixed, Paraffin-Embedded Human Kidney by Immunohistochemistry.
  • ab110051 at 3.75 µg/ml staining Glucose 6 phosphate isomerase in Formalin-Fixed, Paraffin-Embedded Human Testis by Immunohistochemistry.
  • ab110051 at 3.75 µg/ml staining Glucose 6 phosphate isomerase in Formalin-Fixed, Paraffin-Embedded Human Thyroid by Immunohistochemistry.

Anti-Glucose 6 phosphate isomerase antibody (ab110051)参考文献

ab110051 has not yet been referenced specifically in any publications.

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