Anti-Glucokinase抗体(ab76807)

概述

  • 产品名称Anti-Glucokinase抗体
    参阅全部 Glucokinase 一抗
  • 描述
    小鼠单克隆抗体to Glucokinase
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Recombinant fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment corresponding to Human Glucokinase aa 41-142.
    Sequence:

    KKTYRDILTQGKDGVALKCEESGKEAKQAEMQLLVVHLSGSFEVISGRLL KREGHFMPPELLQSQFETLEPPAAPENFIQISVDKNVSEIIATIMETLKM K

性能

应用

Our Abpromise guarantee covers the use of ab76807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 21 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
  • 组织特异性Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
  • 疾病相关Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) [MIM:125851]; also shortened MODY-2. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Defects in GCK are the cause of familial hyperinsulinemic hypoglycemia type 3 (HHF3) [MIM:602485]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
  • 序列相似性Belongs to the hexokinase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ATP:D-hexose 6-phosphotransferase antibody
    • FGQTL3 antibody
    • GCK antibody
    • GK antibody
    • GLK antibody
    • Glucokinase antibody
    • Hexokinase D pancreatic isozyme antibody
    • Hexokinase type IV antibody
    • Hexokinase-4 antibody
    • Hexokinase-D antibody
    • HHF3 antibody
    • HK IV antibody
    • HK4 antibody
    • HKIV antibody
    • HXK4_HUMAN antibody
    • HXKP antibody
    • LGLK antibody
    • MODY2 antibody
    see all

Anti-Glucokinase antibody 图像

  • Anti-Glucokinase antibody (ab76807) at 1/500 dilution + immunogen (GST-tagged 101 residues recombinant fragment of Human C9orf103) at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L) HRP-conjugated at 1/5000 dilution

    Predicted band size : 21 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
    MW of GST tag alone: 26 kDa

Anti-Glucokinase antibody (ab76807)参考文献

ab76807 has not yet been referenced specifically in any publications.

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