概述

  • 产品名称
  • 描述
    兔多克隆抗体to GLRB
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 102-132 of Human GLRB (NP_001159532.1, NP_000815.1).

  • 阳性对照
    • Mouse cerebellum tissue lysate

性能

应用

Our Abpromise guarantee covers the use of ab123886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.

靶标

  • 相关性
    GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.
  • 细胞定位
    Plasma membrane; multi-pass membrane protein.
  • 数据库链接
  • 别名
    • Glycine receptor 58 kDa subunit antibody
    • Glycine receptor beta antibody
    • Glycine receptor subunit beta antibody
    • Glycine receptor, beta subunit antibody
    • OTTHUMP00000220896 antibody
    • OTTHUMP00000220897 antibody
    see all

图片

  • Anti-GLRB antibody (ab123886) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

    Predicted band size : 56 kDa

实验方案

文献

This product has been referenced in:
  • James VM  et al. Novel missense mutations in the glycine receptor ß subunit gene (GLRB) in startle disease. Neurobiol Dis 52:137-49 (2013). WB ; Human . Read more (PubMed: 23238346) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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