Anti-GLP1抗体[EPR4042-407] (ab111125)


  • 产品名称Anti-GLP1抗体[EPR4042-407]
    参阅全部 GLP1 一抗
  • 描述
    兔单克隆抗体[EPR4042-407] to GLP1
  • 经测试应用适用于: ELISA, IHC-Pmore details
    不适用于: IP or WB
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 7-36 of Human GLP1.

  • 阳性对照
    • Human Pancreas tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab111125 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 1 µg/ml.
IHC-P 1/100 - 1/250. Antigen retrieval is recommended. Heat up to 98 °C, below boiling, and then let cool for 10-20 min.
  • 应用说明Is unsuitable for IP or WB.
  • 靶标

    • 功能Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
      GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis.
      GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.
      Oxyntomodulin significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
      Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
    • 组织特异性Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
    • 序列相似性Belongs to the glucagon family.
    • 翻译后修饰Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • GCG antibody
      • glicentin-related polypeptide antibody
      • GLP-1 antibody
      • GLP-1(7-36) antibody
      • GLP-1(7-37) antibody
      • GLP-2 antibody
      • GLP1 antibody
      • GLP1, included antibody
      • GLP2 antibody
      • GLP2, included antibody
      • GLUC_HUMAN antibody
      • Glucagon antibody
      • Glucagon like peptide 1 antibody
      • glucagon-like peptide 1 antibody
      • Glucagon-like peptide 1, included antibody
      • Glucagon-like peptide 2 antibody
      • Glucagon-like peptide 2, included antibody
      • GRPP antibody
      • OXM antibody
      • OXY antibody
      • preproglucagon antibody
      see all

    Anti-GLP1 antibody [EPR4042-407] 图像

    • ELISA: Glucagon-like Peptide (GLP-1) with various concentrations was coated into 96-wells. 1 ug/ml of anti-Glucagon-Like Peptide 1 (GLP-1, 7-36,amide) rabbit monoclonal antibody (ab111125) or the antibody from Vendor X was added. HRP conjugated goat anti-rabbit IgG antibody was used to develop the color.
    • ELISA: 1 ug/ml of GLP-1 was coated into 96-wells. Anti-Glucagon-Like Peptide 1 (GLP-1) rabbit monoclonal antibody (ab11125) or the antibody from Vendor X with various concentrations was added. HRP conjugated goat anti-rabbit IgG antibody was used to develop the color.
    • ab111125 at 1/100 dilution staining GLP1 in paraffin- embedded Human Pancreas tissue by Immunohistochemistry.

    Anti-GLP1 antibody [EPR4042-407] (ab111125)参考文献

    ab111125 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab111125.
    Please use the links above to contact us or submit feedback about this product.