• 产品名称
  • 描述
    兔多克隆抗体to GLE1
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 414 and 656 of GLE1.

  • 阳性对照
    • WB: 293T, A431, HeLa, MOLT4 or Raji cell lysate for WB; ICC/IF: HeLa cells; IHC-P: Cal27 xenograft.



Our Abpromise guarantee covers the use of ab96007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 75 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.


  • 功能
    Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
  • 疾病相关
    Defects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) [MIM:253310]; also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death.
    Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD) [MIM:611890]. LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe.
  • 序列相似性
    Belongs to the GLE1 family.
  • 细胞定位
    Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function and Cytoplasm. Nucleus > nuclear pore complex. Shuttles between the nucleus and the cytoplasm. In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GLE 1 antibody
    • GLE1 antibody
    • GLE1 like protein antibody
    • GLE1 like RNA export mediator antibody
    • GLE1 RNA export mediator homolog antibody
    • GLE1 RNA export mediator like (yeast) antibody
    • GLE1-like protein antibody
    • GLE1_HUMAN antibody
    • GLE1L antibody
    • hGLE1 antibody
    • LCCS 1 antibody
    • LCCS antibody
    • LCCS1 antibody
    • Nucleoporin GLE1 antibody
    see all

Anti-GLE1 antibody 图像

  • Anti-GLE1 antibody (ab96007) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 75 kDa
  • Top panel: immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab96007 at 1/200 dilution.
    Bottom panel: merged with DNA probe.
  • 1/500 ab96007 staining GLE1 in formalin-fixed, paraffin-embedded Cal27 xenograft by immunohistochemistry.

Anti-GLE1 antibody (ab96007)参考文献

ab96007 has not yet been referenced specifically in any publications.

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I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab96007.

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