概述

  • 产品名称Anti-GJB3抗体
    参阅全部 GJB3 一抗
  • 描述
    兔多克隆抗体to GJB3
  • 特异性This antibody reacts with GJB3.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C terminal region of human GJB3.

  • 阳性对照
    • Human hepatocarcinoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
IHC-P 1/50 - 1/100.

靶标

  • 功能One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 疾病相关Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:133200]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
    Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • 序列相似性Belongs to the connexin family. Beta-type (group I) subfamily.
  • 细胞定位Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Connexin 31 antibody
    • Connexin-31 antibody
    • Connexin31 antibody
    • CX 31 antibody
    • Cx31 antibody
    • CXB3_HUMAN antibody
    • DFNA 2 antibody
    • DFNA2 antibody
    • DFNA2B antibody
    • EKV antibody
    • FLJ22486 antibody
    • Gap junction beta 3 protein antibody
    • Gap junction beta-3 protein antibody
    • Gap junction protein beta 3 31kDa antibody
    • Gap junction protein beta 3 antibody
    • GJB 3 antibody
    • Gjb3 antibody
    • MGC102938 antibody
    see all

Anti-GJB3 antibody 图像

  • Formalin fixed and paraffin embedded human hepatocarcinoma tissue reacted with ab59925 at 1/50 dilution, which was peroxidase conjugated to the secondary antibody, followed by AEC staining.

Anti-GJB3 antibody (ab59925)参考文献

ab59925 has not yet been referenced specifically in any publications.

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