Anti-GJB3抗体(ab108285)

概述

  • 产品名称Anti-GJB3抗体
    参阅全部 GJB3 一抗
  • 描述
    兔多克隆抗体to GJB3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Zebrafish
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 (

    MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKD

    ) of Mouse GJB3 (NP_032152.1).

  • 阳性对照
    • SP2/0 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab108285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.125 µg/ml. Predicted molecular weight: 31 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 疾病相关Defects in GJB3 are a cause of erythrokeratodermia variabilis (EKV) [MIM:133200]. EKV is a genodermatosis characterized by the appearance of two independent skin lesions: transient figurate erythematous patches and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
    Defects in GJB3 are the cause of deafness autosomal dominant type 2B (DFNA2B) [MIM:612644]. DFNA2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • 序列相似性Belongs to the connexin family. Beta-type (group I) subfamily.
  • 细胞定位Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Connexin 31 antibody
    • Connexin-31 antibody
    • Connexin31 antibody
    • CX 31 antibody
    • Cx31 antibody
    • CXB3_HUMAN antibody
    • DFNA 2 antibody
    • DFNA2 antibody
    • DFNA2B antibody
    • EKV antibody
    • FLJ22486 antibody
    • Gap junction beta 3 protein antibody
    • Gap junction beta-3 protein antibody
    • Gap junction protein beta 3 31kDa antibody
    • Gap junction protein beta 3 antibody
    • GJB 3 antibody
    • Gjb3 antibody
    • MGC102938 antibody
    see all

Anti-GJB3 antibody 图像

  • Anti-GJB3 antibody (ab108285) at 0.125 µg/ml + SP2/0 cell lysate at 10 µg

    Predicted band size : 31 kDa

Anti-GJB3 antibody (ab108285)参考文献

ab108285 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Mouse Tissue sections (E14.5 wildtype gut)
Specification E14.5 wildtype gut
Fixative Formaldehyde
Permeabilization Yes - 0.1% Triton X-100
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C
Username

Abcam user community

Verified customer

提交于 Jul 19 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"