概述

  • 产品名称Anti-GJA3抗体
    参阅全部 GJA3 一抗
  • 描述
    兔多克隆抗体to GJA3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Pig, Saccharomyces cerevisiae, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 72-121 (ISHIRFWALQ IIFVSTPTLI YLGHVLHIVR MEEKKKEREE EEQLKRESPS) of human GJA3 (NP_068773).

  • 阳性对照
    • 721_B cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab85892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 疾病相关Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
  • 序列相似性Belongs to the connexin family. Alpha-type (group II) subfamily.
  • 细胞定位Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAE3 antibody
    • Connexin 46 antibody
    • Connexin-46 antibody
    • Connexin46 antibody
    • Cx46 antibody
    • CXA3_HUMAN antibody
    • CZP3 antibody
    • Gap junction alpha 3 protein antibody
    • Gap junction alpha-3 protein antibody
    • Gap junction protein, alpha 3, 46kD (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa antibody
    • Gja3 antibody
    see all

Anti-GJA3 antibody 图像

  • Anti-GJA3 antibody (ab85892) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa
    Additional bands at : >90 kDa. We are unsure as to the identity of these extra bands.

Anti-GJA3 antibody (ab85892)参考文献

ab85892 has not yet been referenced specifically in any publications.

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