Anti-Girdin (phospho S1417)抗体(ab111440)


  • 产品名称Anti-Girdin (phospho S1417)抗体
    参阅全部 Girdin 一抗
  • 描述
    兔多克隆抗体to Girdin (phospho S1417)
  • 特异性ab111440 detects endogenous levels of Girdin only when phosphorylated at serine 1417.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from Human Girdin around the phosphorylation site of serine 1417 (Q-K-SP-L-T).

  • 阳性对照
    • Human breast carcinoma tissue



Our Abpromise guarantee covers the use of ab111440 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • 功能Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
  • 组织特异性Expressed ubiquitously.
  • 序列相似性Belongs to the CCDC88 family.
  • 翻译后修饰Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
  • 细胞定位Membrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection > lamellipodium. Localizes to the cell membrane through interaction with phosphoinositides.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AKT iphosphorylation enhancer antibody
    • Akt phosphorylation enhancer antibody
    • APE antibody
    • Ccdc88a antibody
    • Coiled coil domain containing 88A antibody
    • Coiled coil domain containing protein 88A antibody
    • Coiled-coil domain-containing protein 88A antibody
    • FLJ10392 antibody
    • G alpha interacting vesicle associated protein antibody
    • G alpha-interacting vesicle-associated protein antibody
    • Galpha interacting vesicle associated protein antibody
    • Girders of actin filament antibody
    • Girdin antibody
    • GIV antibody
    • GRDN antibody
    • GRDN_HUMAN antibody
    • HkRP1 antibody
    • Hook related protein 1 antibody
    • Hook-related protein 1 antibody
    • KIAA1212 antibody
    see all

Anti-Girdin (phospho S1417) antibody 图像

  • ab111440, at 1/50 dilution, staining Girdin in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-Girdin (phospho S1417) antibody (ab111440)参考文献

ab111440 has not yet been referenced specifically in any publications.

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