Anti-GHRHR抗体(ab28692)
Key features and details
- Rabbit polyclonal to GHRHR
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-GHRHR抗体
参阅全部 GHRHR 一抗 -
描述
兔多克隆抗体to GHRHR -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide:
RTRAKWTTPSRSAAKVLTSM
conjugated to KLH, corresponding to amino acids 403-422 of Human GHRHR -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab28692于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P |
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
说明 |
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IHC-P
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
靶标
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功能
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. -
组织特异性
Pituitary gland. -
疾病相关
Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. -
序列相似性
Belongs to the G-protein coupled receptor 2 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 2692 Human
- Omim: 139191 Human
- SwissProt: Q02643 Human
- Unigene: 767 Human
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别名
- GHRFR antibody
- GHRH R antibody
- GHRH receptor antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (26)
ab28692 被引用在 26 文献中.
- Kubra KT et al. Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells. Endocrines 3:813-820 (2022). PubMed: 36540765
- Akhter MS & Barabutis N Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone. J Biochem Mol Toxicol 35:e22879 (2021). PubMed: 34369038
- Pech-Pool S et al. Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures. Int J Mol Sci 21:N/A (2020). PubMed: 32093298
- Barabutis N et al. GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity. Horm Metab Res 52:336-339 (2020). PubMed: 32403147
- Uddin MA et al. GHRH antagonists support lung endothelial barrier function. Tissue Barriers 7:1669989 (2019). PubMed: 31578921