Anti-Ghrelin抗体(ab19314)

概述

  • 产品名称Anti-Ghrelin抗体
    参阅全部 Ghrelin 一抗
  • 描述
    兔多克隆抗体to Ghrelin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    GSSFLSPEHQRVQQRKESKKPPAKLPQR

    , corresponding to amino acids 24-51 of Human Ghrelin

  • 阳性对照
    • 购买相配的WB阳性对照Recombinant Human Ghrelin protein
    • PA1-1046 detects recombinant human ghrelin. This antibody detect both the octanoylated and non-octanoylated forms of ghrelin. ab19314 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~3 kDa protein representing recombinant human ghrelin.

性能

应用

Our Abpromise guarantee covers the use of ab19314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 3 kDa (predicted molecular weight: 3 kDa).

靶标

  • 功能Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
  • 组织特异性Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
  • 序列相似性Belongs to the motilin family.
  • 翻译后修饰O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.
    Amidation of Leu-98 is essential for obestatin activity.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Appetite regulating hormone antibody
    • Ghrelin 27 antibody
    • Ghrelin 28 antibody
    • Ghrelin and obestatin prepropeptide antibody
    • Ghrelin antibody
    • Ghrelin/obestatin prepropeptide antibody
    • ghrl antibody
    • GHRL_HUMAN antibody
    • Growth hormone releasing peptide antibody
    • Growth hormone secretagogue antibody
    • Growth hormone-releasing peptide antibody
    • M46 protein antibody
    • Motilin related peptide antibody
    • Motilin-related peptide antibody
    • MTLRP antibody
    • Obestatin antibody
    • Protein M46 antibody
    see all

Anti-Ghrelin antibody (ab19314)参考文献

ab19314 has not yet been referenced specifically in any publications.

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According to SwissProt, O-octanoylation or O-decanoylation is essential for Ghrelin activity. As this antibody detects both the octanoylated and non-octanoylated forms of Ghrelin, the antibody detects therefore both th...

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Thank you for your patience. I am sorry to hear that you have been experiencing problems with ab19314 in western blot. Often it is possible to make suggestions that help resolve problems. We will happily offer technical support and in the event that...

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Thank you for your enquiry. I contacted the originator of the antibody and there is no data regarding the detection of the unprocessed full-length precursor protein at this time. The antibody has been tested against recombinant human Ghrelin. It ma...

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Thank you for your enquiry. I have been in touch with the source of the antibodies that you are interested in and I can tell you that with regards to Anti-Ghrelin ab19314 this antibody was tested using recombinant human ghrelin. However, the highes...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"