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Synthetic peptide, corresponding to amino acids 347-360 of Mouse GFR alpha 3.
Members of the glial cell line-derived neurotrophic factor(GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Our Abpromise guarantee covers the use of ab8028 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC (PFA fixed)||1/50.|
|IHC-P||Use a concentration of 10 µg/ml.|
|WB||1/500 - 1/1000. Predicted molecular weight: 43 kDa.Can be blocked with GFR alpha 3 peptide (ab6100).|
ab8028 at 10µg/ml staining GFR alpha 3 in mouse heart tissue by IHC-P.