Anti-GFAP抗体[MIG-G2] (ab51837)

概述

  • 产品名称Anti-GFAP抗体[MIG-G2]
    参阅全部 GFAP 一抗
  • 描述
    小鼠单克隆抗体[MIG-G2] to GFAP
  • 特异性GFAP, no cross-reactivity with other filament proteins.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Rat, Guinea pig, Human
  • 免疫原

    Purified Glial Fibrillary Acidic Protein.

  • 阳性对照
    • Glioma, Astrocytoma.
  • 常规说明


    ab51837 is helpful in differentiation of central nervous tumours. The antibody will specifically label glioblastoma, astrocytoma and medulloblastoma.

性能

应用

Our Abpromise guarantee covers the use of ab51837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/10 - 1/25.

No protease pre-treatment. Blocking of endogenous enzymes is recommended, depending on kind of secondary reagents. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test).

靶标

  • 功能GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
  • 组织特异性Expressed in cells lacking fibronectin.
  • 疾病相关Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰Phosphorylated by PKN1.
  • 细胞定位Cytoplasm. Associated with intermediate filaments.
  • Information by UniProt
  • 数据库链接
  • 别名
    • wu:fb34h11 antibody
    • ALXDRD antibody
    • cb345 antibody
    • etID36982.3 antibody
    • FLJ42474 antibody
    • FLJ45472 antibody
    • GFAP antibody
    • GFAP_HUMAN antibody
    • gfapl antibody
    • Glial fibrillary acidic protein antibody
    • Intermediate filament protein antibody
    • wu:fk42c12 antibody
    • xx:af506734 antibody
    • zgc:110485 antibody
    see all

Anti-GFAP antibody [MIG-G2] (ab51837)参考文献

ab51837 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"